Meclonazepam sensitivity of parasitic flatworms correlates with TRPM_MCLZ sensitivity to meclonazepam.

ABSTRACT: The ionotropic portfolio of parasitic flatworms affords considerable opportunity for development of new anthelmintics. In this regard, transient receptor potential ion channels (TRP channels), cation channels responsive to various physiochemical cues, have emerged as promising druggable targets. This is based on the recent discovery that two members of a TRP channel subfamily (TRP melastatin or TRPM channels) are selectively activated by the clinical drug praziquantel (TRPM_PZQ), or the anthelmintic benzodiazepine meclonazepam (TRPM_MCLZ). Here, the efficacy of meclonazepam was investigated in a trematode (the liver fluke, Fasciola hepatica) and a cestode (Echinococcus multilocularis) model, in which an observed lack of meclonazepam sensitivity correlated with the lack

SUBMITTER: Rohr CM 

PROVIDER: S-EPMC12861061 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature