Tumor Microenvironments in Malignant Ovarian Germ Cell Tumors: MHC Class I Loss and T-Cell Exhaustion in Dysgerminoma.

ABSTRACT: Malignant ovarian germ cell tumors are rare neoplasms primarily affecting young women. Although generally responsive to chemotherapy, long-term adverse effects remain a concern. Improved understanding of the tumor microenvironment may reveal alternative therapeutic strategies; however, comprehensive analyses in malignant ovarian germ cell tumors remain limited. We analyzed 56 malignant ovarian germ cell tumor samples: 23 dysgerminomas, 14 yolk sac tumors, and 19 immature teratomas. Immune cell infiltration and immune checkpoint molecule expression were evaluated via immunohistochemistry, while immune-related gene expression was assessed using transcriptomic profiling. In dysgerminoma, T-cell exhaustion was characterized through multiplex immunofluorescence. Major histocompatibility complex

SUBMITTER: Nakashima M 

PROVIDER: S-EPMC12861093 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature