Spatial Location of SPP1⁺TAMs and Mutually Exclusive Subsets Based on Single-Cell and Transcriptome Data.

ABSTRACT: To clarify locations and mutually exclusive subsets of SPP1⁺tumor associated macrophages (SPP1⁺TAMs) in lung adenocarcinoma (LUAD). Analyze the polarization type, mutually exclusive cell subset, and spatial location of SPP1⁺TAMs based on the transcriptome data of the Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) database, single-cell and spatial transcriptome data of the Gene Expression Omnibus database (GEO), immunohistochemical data of the Human Protein Atlas (HPA) database and local LUAD to provide a scientific basis for precision treatment of LUAD. Secreted phosphoprotein-1 (SPP1) was identified as the central regulatory gene of LUAD. The single-cell transcriptome data showed that SPP1 is up-regulated in invasive lung carcinoma (ILC),

SUBMITTER: Luo X 

PROVIDER: S-EPMC12861114 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature