Effect of selenium yeast supplementation on drug metabolism genes, oxidative stress, and apoptosis in chicken liver after diquat induction: A proteomic perspective.

ABSTRACT: Selenium yeast (SeY) is a commonly used beneficial additive in animal feed, but its effectiveness in reducing diquat (DQ)-induced liver damage remains uncertain. This study examined how selenium yeast affects drug-metabolism genes, oxidative stress, and apoptosis in chicken liver using proteomics and validation experiments. Proteomic analysis identified 2,233 differentially expressed proteins, including 786 upregulated and 1,447 downregulated. In the SeY group compared with the diquat group, 197 proteins were upregulated and 327 downregulated. Enrichment analysis indicated that these proteins were mainly involved in ribosome synthesis, linoleic acid metabolism, and steroid biosynthesis. The protein interaction network revealed key roles in regulating ribosome function, antioxidant systems,

SUBMITTER: Gao F 

PROVIDER: S-EPMC12861162 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature