Home-Based Exercise Improves Muscle Oxidative Capacity in Kidney Disease.

ABSTRACT:

Introduction

Muscle impairment in chronic kidney disease (CKD) contributes to decreased physical performance, frailty, and increased mortality. This proof-of-concept randomized controlled study evaluated the efficacy of a 12-week home-based, video-supervised exercise program on muscle endurance in moderate-to-severe nondialysis CKD.

Methods

Thirty-two sedentary adults with CKD (estimated glomerular filtration rate [eGFR] < 60 ml/min per 1.73 m²) were randomized (3:1) to a home exercise group (EX, n = 23) or usual care group (UC, n = 9). The primary outcome was in vivo muscle mitochondrial bioenergetics (rate of phosphocreatine recovery, k_PCr) measured using phosphorus-31 magnetic resonance spectroscopy. Secondary outcomes included 6

SUBMITTER: Begue G 

PROVIDER: S-EPMC12861209 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature