Associations of biomarkers with hypoattenuated leaflet thickening after transcatheter aortic valve replacement.

ABSTRACT:

Background

Patients after transcatheter aortic valve replacement (TAVR) have a high incidence of hypoattenuating leaflet thickening (HALT). However, data on biomarkers related to HALT remain limited.

Objectives

To identify hemostatic markers associated with HALT following TAVR.

Methods

This prospective single-center cohort study assessed hemostatic profiles of patients undergoing TAVR between November 2020 and June 2022 using thrombelastography, light transmission aggregometry, and conventional laboratory markers. The primary outcome was moderate-to-severe HALT (grade 3/4) or reduced leaflet motion (grade 2/3) detected by computed tomography angiography at 6 months post-TAVR.

Results

Of the 107 patients included, 68 had interpretable computed tomography angiogr

SUBMITTER: Hesselbarth D 

PROVIDER: S-EPMC12861211 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature