Meis1 Negatively Regulates Epithelial-Mesenchymal Transition via Wnt/β-catenin Pathway in Oral Submucous Fibrosis.

ABSTRACT:

Objectives

Oral submucous fibrosis (OSF) is an irreversible and potentially malignant oral disorder. Epithelial-mesenchymal transition (EMT) is a key driver of its pathogenesis. However, the underlying molecular mechanisms remain incompletely elucidated. This study aimed to investigate the role of Meis1, a novel regulatory molecule, in the pathogenesis of OSF and explore its underlying mechanism.

Materials and methods

Bioinformatics analysis explored the correlation between Meis1 and OSF. Meis1 expression in clinical OSF tissues and cell models was verified by q-PCR, western blotting, and immunohistochemistry. Cell migration and proliferation were assessed via wound healing assays and EDU staining. RNA sequencing identified Meis1's downstream pathways. Rescue experiments det

SUBMITTER: Cai J 

PROVIDER: S-EPMC12861223 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature