Method development with LA-ICP-MS in U-Pb geochronology using design of experiment.

ABSTRACT: Inductively Coupled Plasma Mass Spectrometry (ICP-MS), when combined with laser ablation (LA-ICP-MS), is widely used for precise U-Pb zircon geochronology. While the technique is powerful, reliable age determinations depend on careful optimization of laser and plasma parameters of the instrument. In this study, we used a Sector Field ICP-MS (Thermo Scientific Element 2) coupled to a New Wave UP213 laser to present practical, step-by-step measurement and optimization procedures for geological U-Pb dating. Here, Design of Experiments (DoE)-a statistical approach that evaluates multiple parameters simultaneously and reveals their interactions-was used to efficiently determine optimal analytical conditions with a limited number of experiments. For the first time in LA-ICP-MS research, a DoE fr

SUBMITTER: Caner M 

PROVIDER: S-EPMC12861260 | biostudies-literature | 2026 Jun

REPOSITORIES: biostudies-literature