Diagnostic Value of Transabdominal Ultrasound-based Versus Magnetic Resonance Imaging-based Prostate-specific Antigen Density for Clinically Significant Prostate Cancer.

ABSTRACT:

Background and objective

Prostate-specific antigen (PSA) density (PSAD) improves risk stratification for clinically significant prostate cancer (csPCa) but depends on prostate volume estimation. Transrectal ultrasound is used widely, whereas transabdominal ultrasound (TAUS) is underexplored due to accuracy concerns. We compared PSAD derived from manual magnetic resonance imaging (MRI) segmentation, MRI ellipsoid, and TAUS ellipsoid.

Methods

In a single-centre retrospective cohort, men who underwent biopsy or prostatectomy with histopathological confirmation were included. (1) Manual MRI segmentation versus (2) ellipsoid formulae derived from MRI and TAUS diameters were compared. We evaluated discrimination (area under the curve [AUC]), decision curve net benefit, method agre

SUBMITTER: Xu Z 

PROVIDER: S-EPMC12861266 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature