Cerebellar-Prefrontal Connectivity Predicts Negative Symptom Severity Across the Psychosis Spectrum.

ABSTRACT:

Background

Negative symptom severity predicts functional outcomes and quality of life in people with psychosis. However, negative symptoms respond poorly to medication, and existing literature has not converged on their neurobiological basis. Previous work in small schizophrenia samples has observed that lower cerebellar-dorsolateral prefrontal cortex (DLPFC) connectivity is associated with higher negative symptom severity and that increasing cerebellar-DLPFC connectivity with neuromodulation reduces negative symptoms. We extended this finding by testing associations between cerebellar-DLPFC connectivity, negative symptoms, and cognitive performance in a large sample of individuals with psychosis.

Methods

Individuals with psychosis spectrum disorders (N = 260) underwent rest

SUBMITTER: Yarrell SA 

PROVIDER: S-EPMC12861324 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature