Interaction between Neighborhood Exposome and Genetic Risk in Child Persistent Distressing Psychotic-like Experiences.

ABSTRACT: The genetic risk of persistent distressing psychotic-like experiences (PLE) in the multi-ancestral population is under-investigated. The gene-neighborhood environment interaction in persistent distressing PLE is also unknown. This study included 6,449 participants from the Adolescent Brain and Cognitive Development Study. Genetic risk was measured by a multi-ancestral schizophrenia polygenic risk score (SCZ-PRS). Multi-dimensional neighborhood-level exposures were used to form the neighborhood exposome (NE). SCZ-PRS was not statistically significantly associated with odds of persistent distressing PLE (OR = 1.04, 95% CI: 0.97, 1.13, P = 0.280), whereas NE score was (OR = 1.15, 95% CI: 1.05, 1.26, P = 0.003). A significant negative multiplicative interaction between SCZ-PRS an

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12861328 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature