Systemic immune-inflammation index and systemic inflammation response index as predictors of mortality in participants with and without cancer.

ABSTRACT: ObjectiveThe objective of this study was to examine the associations of the systemic immune-inflammation index and the systemic inflammation response index with all-cause and cardiovascular mortality in cancer and noncancer populations.MethodsWe analyzed data from 42,503 adults in the National Health and Nutrition Examination Survey using Cox models and restricted cubic spline analyses.ResultsCompared with the lowest tertile, the highest systemic immune-inflammation index tertile was associated with increased risks of all-cause mortality (hazard ratio, 1.24; 95% confidence interval: 1.16-1.32) and cardiovascular mortality (hazard ratio, 1.29; 95% confidence interval: 1.15-1.45). The highest systemic inflammation response index tertile demonstrated similar increases in all-cause mortality (

SUBMITTER: Hu X 

PROVIDER: S-EPMC12861372 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature