Global Burden of Vertebral Fractures in Women by Menopausal Status, 1990-2021, With 2050 Projections: An Analysis of Global Burden of Disease 2021.

ABSTRACT: Study DesignEco-epidemiological study.ObjectivesVertebral fractures (VFs) are a major cause of morbidity, disability, and mortality in women, with risk increasing sharply after menopause due to accelerated bone loss. However, global patterns of VF burden by menopausal status and long-term projections remain poorly characterized.MethodsWe analyzed Global Burden of Disease (GBD) 2021 data on VF incidence, prevalence, and years lived with disability (YLDs) for 204 countries from 1990-2021. Women were categorized as premenopausal (15-49 years) or postmenopausal (≥50 years). Age-standardized rates (ASRs) were calculated per 100,000 population. Temporal trends were assessed using estimated annual percentage change and joinpoint regression. Socio-demographic disparities were examined with Slope I

SUBMITTER: Fan J 

PROVIDER: S-EPMC12861415 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature