Clinical Outcomes of Aerosolized Versus Intravenous Colistin in Ventilator-Associated Pneumonia Caused by Multidrug-Resistant Gram-Negative Bacteria.

ABSTRACT:

Background

Ventilator-associated pneumonia (VAP) caused by multidrug-resistant (MDR) Gram-negative bacteria has presented significant treatment challenges in critical care. While intravenous colistin is commonly used, its nephrotoxicity and limited lung penetration raise concerns. This study aimed to compare the clinical efficacy and safety of aerosolized versus intravenous colistin in patients with VAP.

Methods

The study included 60 adult patients diagnosed with VAP caused by colistin-sensitive MDR Gram-negative bacteria. Treatment decisions (aerosolized or intravenous colistin) were made by attending physicians based on clinical judgment (n = 30 per each group). The primary outcome was clinical success; secondary outcomes included time to defervescence, Clinical Pulmonary

SUBMITTER: Loi DV 

PROVIDER: S-EPMC12861513 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature