Exposure to Ambient Heat and Risk of Spontaneous Abortion: A Case-Crossover Study.

ABSTRACT:

Background

Few epidemiologic studies have examined the association of ambient heat with spontaneous abortion, a common and devastating pregnancy outcome.

Methods

We conducted a case-crossover study nested within Pregnancy Study Online, a preconception cohort study (2013-2022). We included all participants reporting spontaneous abortion (N = 1,524). We defined the case window as the 7 days preceding the event and used time-stratified referent selection to select control windows matched on calendar month and day of week. Within each 7-day case and control window, we measured the mean, maximum, and minimum of daily maximum outdoor air temperatures. We fit splines to examine nonlinear relationships across the entire year and conditional logistic regression to estimate odds ratio

SUBMITTER: Wesselink AK 

PROVIDER: S-EPMC12861555 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature