Meflin/ISLR is a meningeal cell-specific marker involved in the development of meninges and meningioma progression.

ABSTRACT: The meninges, which originate from the neural crest cells and mesoderm, play crucial roles in the formation, protection, and homeostasis of the central nervous system. Meningiomas, which arise from the meninges, are the most common primary intracranial tumors, and their recurrence and malignant transformation represent major clinical challenges. Recent studies have identified mesenchymal stromal cell- and fibroblast-expressing Linx paralogue (Meflin), as being expressed in the meninges, but its role in meningeal development and meningioma pathophysiology remains poorly understood. In this study, we investigated the expression patterns of Meflin during meningeal development and in meningioma tissues. Meflin expression was detected in the head of a Meflin reporter mouse line at approximately

SUBMITTER: Shiraki Y 

PROVIDER: S-EPMC12861569 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature