Cell Toxicity and Autophagy in A549 Cells Treated With Surface-Functionalized Graphene Derivatives.

ABSTRACT: Graphene oxide and its derivatives have unique physical and chemical properties with applications in many different fields. However, their biological effects and mechanisms of intracellular toxicity have not been completely clarified. In this study, we investigated the cytotoxic and autophagic activities of graphene oxide and its derivatives in A549 human lung carcinoma cells. In the experimental procedure, A549 cells were treated with graphene oxide (GO), dodecylamine-oxidized graphene (DA-GO), reduced graphene oxide (rGO), and sodium dodecyl sulfate-reduced graphene oxide (SDS-rGO), and their cytotoxicity and protein expression levels were measured. Treating A549 cells with each type of graphene induced a concentration-dependent toxic effect on the cells, with no obvious cytotoxicity at

SUBMITTER: Park TY 

PROVIDER: S-EPMC12861601 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature