Cardiac resynchronization therapy in chronic Chagas cardiomyopathy: A systematic review and single-arm meta-analysis.

ABSTRACT:

Background

Cardiac resynchronization therapy (CRT) is a well-established therapy for patients with heart failure. However, patients with chronic Chagas cardiomyopathy (CCC) were underrepresented in pivotal CRT trials.

Objective

This systematic review and meta-analysis aim to quantitatively describe the outcomes of CRT in patients with CCC.

Methods

We systematically searched PubMed, Embase, Cochrane, and LILACS registries for studies evaluating the response to CRT in patients with CCC. We applied no language or date restrictions. We applied an inverse-variance random-effects model for a meta-analysis of proportions.

Results

We included 4 observational cohort studies comprising 250 patients with CCC undergoing CRT. At CRT implantation, the mean age was 59 ± 12 ye

SUBMITTER: Ferreira Felix I 

PROVIDER: S-EPMC12861669 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature