Transcatheter Aortic Valve Replacement Associated With Fibrin-Associated Large B-Cell Lymphoma.

ABSTRACT:

Background

Fibrin-associated large B-cell lymphoma (FA-LBCL) is a rare disorder, but its role in transcatheter valve failure is unknown. This report describes the first documented case of FA-LBCL in a transcatheter aortic valve.

First-in-human/early reports summary

A 62-year-old man with a prior transcatheter aortic valve replacement presented with symptomatic severe aortic stenosis. Histopathologic analysis of the explanted valve revealed FA-LBCL as the primary cause of valve failure.

Discussion

This case established a neoplastic process as a cause of structural valve degeneration (SVD) in transcatheter valves. It highlights that FA-LBCL should be included in the differential diagnosis of transcatheter aortic valve replacement failure, for which surgical explantation

SUBMITTER: Tharakan AK 

PROVIDER: S-EPMC12861670 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature