Circulating miRNAs combined with AFP improve diagnostic accuracy for HBV-associated hepatocellular carcinoma.

ABSTRACT:

Background

Early detection of hepatocellular carcinoma (HCC) remains challenging due to the suboptimal diagnostic accuracy of alpha-fetoprotein (AFP). Circulating microRNAs (miRNAs), given their blood stability and role in cancer biology, have emerged as promising non-invasive biomarkers. This study aimed to assess the diagnostic value of serum miR-21-5p, miR-34a-5p, and miR-30d-3p, individually and in combination with AFP, for distinguishing HBV-related HCC from chronic hepatitis B (CHB) and liver cirrhosis (LC) in a Vietnamese patient cohort.

Methods

A total of 450 participants were recruited, including 150 patients with HBV-related HCC, 150 with HBV-related LC, and 150 with CHB. Serum miRNA expression levels were quantified using RT-qPCR and were assessed for the diagnost

SUBMITTER: Dieu Hoa N 

PROVIDER: S-EPMC12861703 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature