High-dose postpartum thromboprophylaxis in women at high risk of pregnancy-related venous thromboembolism: a single-center prospective cohort study.

ABSTRACT:

Background

Pregnancy-related venous thromboembolism (VTE) is a major cause of maternal mortality and morbidity. While thromboprophylaxis can reduce the incidence of VTE, it may increase the risk of bleeding. Current guidelines recommend assessing VTE risk in pregnant women and administering low-molecular-weight heparin (LMWH) thromboprophylaxis to those at high risk. However, there is a paucity of evidence regarding the optimal dosing of postpartum LMWH thromboprophylaxis.

Objectives

To evaluate the safety and efficacy of fixed low-dose LMWH antepartum and weight-based high-dose LMWH (equivalent to weight-based therapeutic-dose LMWH) until 6 weeks postpartum in a prospective cohort of women at high risk for pregnancy-related VTE.

Methods

From December 8, 2014, to Nove

SUBMITTER: Rivrud SCS 

PROVIDER: S-EPMC12861745 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature