Associations between functional autoantibodies targeting GPCRs, antinuclear antibodies, and inflammatory cytokines TNF-α: a cross-sectional study of 19,810 individuals.

ABSTRACT:

Introduction

Functional autoantibodies targeting G protein-coupled receptors (GPCR-AAbs) have increasingly been implicated in autoimmune and inflammatory diseases. However, their relationships with established autoimmune biomarkers, such as antinuclear antibodies (ANA), and key inflammatory cytokines remain insufficiently understood. This study aimed to investigate the associations between different functional GPCR-AAbs, ANA positivity, and inflammatory cytokines, with a particular focus on potential sex-specific effects.

Methods

We conducted a cross-sectional analysis of 19,810 individuals from a large clinic-based cohort. Serum concentrations of functional GPCR-AAbs (Igβ1AR-AAb, Igβ2AR-AAb, IgM3MR-AAb, IgM4MR-AAb, IgETAR-AAb, and IgAT1R-AAb), ANA titers, and the inflammato

SUBMITTER: Chen X 

PROVIDER: S-EPMC12861881 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature