Global trends and forecasts of nonalcoholic steatohepatitis causing liver cancer incidence and deaths.

ABSTRACT:

Background

Metabolic dysfunction-associated steatotic liver disease (MASLD), particularly its progressive form, nonalcoholic steatohepatitis (NASH), has emerged as a leading cause of hepatocellular carcinoma (HCC). The burden of MASLD is increasing rapidly in parallel with the rising global prevalence of obesity and metabolic syndrome, affecting approximately 30% of the world's population.

Objective

This study aimed to quantify global trends in NASH-related liver cancer incidence, mortality, and disability-adjusted life years (DALYs) from 1990 to 2021 and to project the future disease burden through 2035.

Methods

Data from the Global Burden of Disease Study 2021, encompassing 204 countries, were utilized to evaluate age-standardized incidence (ASIR), mortality (ASMR),

SUBMITTER: Cui T 

PROVIDER: S-EPMC12861896 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature