Combining degree centrality and betweenness centrality of molecular networks can effectively pinpoint individuals at high risk of HIV transmission within the network.

ABSTRACT:

Introduction

HIV molecular network technology can identify HIV transmission hotspots and individuals at risk of HIV transmission, facilitating precise and targeted interventions. This study explored the molecular network parameters, namely degree centrality (DC) and betweenness centrality (BC), to effectively pinpoint individuals at high risk of HIV transmission within the network.

Methods

A previous whole-population sampling cohort comprising all newly diagnosed people living with HIV (PLWH) in Shenyang, from 2016 to 2019, was analyzed. Molecular networks based pol gene were constructed, the DC and BC of each node were calculated, and six groups of nodes were identified based on DC, BC, and DC+BC: high DC group, low DC group, high BC group, low BC group, high DC+BC group, a

SUBMITTER: Gan W 

PROVIDER: S-EPMC12861916 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature