Leveraging High-Fidelity Mode for Improved Online Adaptive Stereotactic Accelerated Partial Breast Treatment Efficiency.

ABSTRACT:

Purpose

Cone beam computed tomography guided online adaptive radiation therapy (OART) for stereotactic accelerated partial breast irradiation (APBI) can help mitigate the effects of interfraction lumpectomy bed variation. However, OART leads to a prolonged treatment time due to daily reoptimization of the treatment plan, potentially increasing patient discomfort and intrafraction variation. Here, we investigate the feasibility of using a stereotactic radiation therapy optimization feature, high-fidelity (HF) mode, through an in silico analysis of the entire APBI OART session.

Methods and materials

This retrospective in silico institutional review board-approved study included 25 patient data sets; 10 training patients allowed for iterative tuning of an HF planning strategy a

SUBMITTER: Pogue JA 

PROVIDER: S-EPMC12861973 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature