High burden of geriatric assessment impairments across the adult age spectrum in patients with cancer.

ABSTRACT:

Background

The age-specific distribution of frailty and its domain-level characteristics remain poorly understood across the adult population of patients with cancer. We aimed to quantify the frailty prevalence and geriatric assessment (GA) impairment patterns in adults and to examine their prognostic relevance in newly diagnosed patients with cancer.

Material and methods

This multicenter, cross-sectional cohort enrolled 2,501 adults (≥20 years) before therapy in 2021-2023. GA covered 8 domains (function, comorbidity, cognition, mood, nutrition, polypharmacy, falls, and social support). Patients were grouped into 6 age bands (20-39 to ≥80) and labeled fit (0 deficits), prefrail (1), or frail (≥2). We analyzed age-specific geriatric impairment patterns and overall survival (O

SUBMITTER: Nien CT 

PROVIDER: S-EPMC12861979 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature