C-Reactive Protein and Neutrophil-To-Lymphocyte Ratio: Can They Be Used Interchangeably in Tracking Clozapine-Related Inflammation?

ABSTRACT:

Background

Clozapine initiation often triggers inflammatory responses that can alter metabolism via Cytochrome P450 1A2 (CYP1A2) suppression. Although C-reactive protein (CRP) is the recommended marker, it may be unavailable in community settings. Neutrophil-to-lymphocyte ratio (NLR), routinely measured, could serve as a surrogate, though its value in detecting clozapine-related inflammation and metabolic changes remains unclear.

Aims

This study aimed to assess the relationship between CRP and NLR in individuals treated with clozapine, evaluate whether NLR can act as a proxy for elevated CRP (> 5 mg/L), and determine whether NLR, like CRP, explains variability in clozapine metabolism (concentration to dose (C/D) ratios) after adjusting for covariates.

Methods

We perfo

SUBMITTER: Bihelek N 

PROVIDER: S-EPMC12862047 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature