Long-term nitric oxide exposure induces cough hypersensitivity via non-inflammatory activation of the HIF1α-TRPV1 pathway.

ABSTRACT:

Background

Chronic cough hypersensitivity is common across respiratory diseases and often occurs without airway inflammation, yet effective treatments remain limited. Nitric oxide (NO), an important endogenous signaling molecule and environmental pollutant, has been implicated in respiratory pathophysiology, but its role in cough hypersensitivity remains unclear.

Aim

The aim of this study was to investigate whether long-term NO exposure induces cough hypersensitivity and to define the underlying mechanisms involved.

Methods

A guinea pig model of chronic NO exposure was established and compared with a cigarette smoke (CS) -induced cough model. Cough sensitivity was assessed using capsaicin challenge tests. Airway pathology and inflammation were evaluated by histologica

SUBMITTER: Zhao J 

PROVIDER: S-EPMC12862251 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature