Plasma Proteomic Profile of Chemotherapy-Induced Severe Neutropenia: A Pilot Discovery Phase Study.

ABSTRACT: Transient severe neutropenia and thrombocytopenia are frequent during treatment of hematological malignancies and contribute to early mortality through sepsis and bleeding. While neutrophils and platelets are essential for host defense and tissue repair, little is known about immune adaptations during their depletion. In this pilot, discovery phase study, we evaluated the plasma proteome of 10 patients with chemotherapy-induced severe neutropenia and thrombocytopenia, prior to any clinical complication. At sampling, mean neutrophil and platelet counts were 0.15 ± 0.18 × 10⁹/L and 34.6 ± 17.4 × 10⁹/L, respectively. A total of 762 proteins were identified, of which 71 were downregulated and 21 were upregulated in patients compared with healthy controls. Over-representat

SUBMITTER: da Silva LQ 

PROVIDER: S-EPMC12862286 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature