Changing donors improves outcomes of second transplantation in patients who experienced graft failure after first allogeneic stem cell transplantation.

ABSTRACT: A second transplantation is almost the only salvage for patients encountering graft failure (GF) following first allogeneic stem cell transplantation. However, there were no standard protocols for second transplantations, and the role of changing donors remained controversial. We retrospectively studied 272 consecutive patients from 18 Chinese centers undergoing second transplantations due to GF, aiming to assess the impact of changing donors and the factors affecting second transplantation outcomes. The primary endpoint was neutrophil engraftment. Other endpoints included platelet engraftment, graft-versushost disease (GvHD), transplant-related mortality (TRM), relapse, and survival. Of the 272 patients, 193 (71.0%) patients experienced primary GF, and 70.6% (192) used a different second

SUBMITTER: Ma R 

PROVIDER: S-EPMC12862326 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature