Dental plaque microbiota following allogeneic hematopoietic cell transplantation and risk of chronic graft-<i>versus</i>-host disease.

ABSTRACT: Microbiota disruptions have been associated with short-term complications after allogeneic hematopoietic cell transplantation (alloHCT). However, only a few studies have examined the relationship between dysbiosis and chronic graft-versus-host disease (cGvHD), the main long-term immunologic toxicity of alloHCT. Considering the role of oral microbiota in systemic inflammatory diseases, we evaluated whether oral microbiota at day 28 post HCT corresponding to clinical recovery from the acute events after transplantation is associated with subsequent cGvHD. Shotgun metagenomic sequencing of 207 saliva and supragingival plaque samples collected longitudinally at baseline (pre-conditioning), day +28, and day +84 from 37 patients (11 with subsequent moderate/severe cGvHD) revealed a significant a

SUBMITTER: Gem H 

PROVIDER: S-EPMC12862331 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature