Liver transplantation for HCC with macrovascular invasion: A systematic review and meta-analysis of observational studies.

ABSTRACT:

Background & aims

Traditional guidelines discourage liver transplantation (LT) in patients with hepatocellular carcinoma (HCC) with macrovascular invasion (MVI). However, emerging evidence suggests that long-term survival is possible when LT is preceded by downstaging therapies. Thus, a pooled analysis of time-dependent risk factor effect size on overall survival (OS) is warranted to determine the effect size of MVI, estimate risk mitigation through downstaging, and design future trials.

Methods

MEDLINE, EMBASE, Cochrane Database of Systematic Reviews, and the Cochrane Register were systematically searched from their inception to 24 January 2023. Studies with comparative oncological outcome data between patients with HCC and MVI (MVI group) and HCC patients without MVI (non-

SUBMITTER: Ladak F 

PROVIDER: S-EPMC12862345 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature