Disease activity and mental health symptoms in axial spondyloarthritis: concordant or discordant?

ABSTRACT:

Objective

We applied latent class and trajectory modelling to examine whether subgroups of axial spondylarthritis (axSpA) patients report discordant scores for disease activity and mental health symptoms at baseline and after treatment change.

Methods

We analysed axSpA patients from the ASAS Health Index International Validation Study. We applied latent class analysis (LCA) using generalized structural equation modelling to identify subgroups among 1292 individuals, based on baseline Hospital Anxiety and Depression Scale (HADS) subscores and ASDAS. We applied trajectory modelling in a subset (n = 206) requiring treatment change, to identify subgroups of distinct trajectories for HADS and ASDAS over 6 months. All indices were standardized. Baseline characteristics were compar

SUBMITTER: Zhao SS 

PROVIDER: S-EPMC12862361 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature