Fine particulate matter air pollution and anti-nuclear antibodies.

ABSTRACT:

Objectives

Air pollution has been increasingly linked to systemic autoimmune rheumatic diseases (SARDs), but studies regarding fine particulate matter (PM2.5) and SARD-related serological biomarkers are limited. We aimed to assess the association between exposure to ambient PM2.5 and ANA in the general population.

Methods

Serum samples of 3548 subjects (collected between 2010 and 2013) were randomly selected from the Ontario Health Study general population cohort. We examined ANA titres using indirect immunofluorescence assay on HEp-2 cells. Annual average ambient PM2.5 levels (estimated by satellite images and a chemical transport model) for the 5-year period before sera collection were assigned based on subjects' six-character residential postal codes. We used multivariabl

SUBMITTER: Zhao N 

PROVIDER: S-EPMC12862395 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature