Neurofilament Light Chain Concentration in the Prediction of Treatment Response in Multiple Sclerosis.

ABSTRACT:

Introduction

Management of multiple sclerosis (MS) revolves around timely initiation of effective disease-modifying therapy. Here we investigate the additive predictive value of age-adjusted normalised neurofilament light chain (NfL) concentrations when combined with a clinicodemographic model of treatment response.

Methods

Data were obtained from three sources: the University Hospital Basel, the SET cohort in Prague, and EIMS and IMSE cohorts from Sweden. NfL samples were collected within 90 days of baseline, age-adjusted and normalised using a reference population. Principal component analysis reduced the dimensionality of clinicodemographic predictors. Cox proportional hazards models estimated cumulative hazards of relapse, 6-month confirmed disability worsening and 9-mon

SUBMITTER: Moradi N 

PROVIDER: S-EPMC12862443 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature