Arterial-Washout Temporal Profiling in CEUS LI-RADS: A Diagnostic Algorithm for Reducing Hepatocellular Carcinoma Misclassification.

ABSTRACT: Purpose To determine whether combining the arterial phase onset time to washout onset time interval (AWTI) with washout onset time improves the accuracy of contrast-enhanced US (CEUS) Liver Imaging Reporting and Data System (LI-RADS) and reduces the incidence of hepatocellular carcinoma (HCC) being misclassified as LR-M. Materials and Methods CEUS and clinical data from patients with focal liver lesions (FLLs), collected between January 2019 and October 2024, were retrospectively analyzed. The AWTI was calculated for all FLLs with washout < 60 seconds. A revised classification was proposed: (a) washout < 45 seconds + AWTI < 21 seconds for LR-M; and (b) washout ≥ 45 seconds + AWTI ≥ 21 seconds for LR-5. Diagnostic performance of the revised classification was compared with tha

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12862477 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature