Prognostic Biomarkers for Predicting Decompensation in Alcoholic and Nonalcoholic Patients With Compensated Cirrhosis: An Umbrella Review.

ABSTRACT:

Introduction

Compensated cirrhosis carries a significant risk of progression to decompensation, which substantially worsens prognosis. Accurate prediction of decompensation events is critical for guiding surveillance, optimizing intervention timing, and improving patient outcomes. Although many prognostic biomarkers have been studied, findings remain heterogeneous. This umbrella review synthesizes evidence from systematic reviews and meta-analyses to identify and appraise biomarkers predicting decompensation in alcoholic and nonalcoholic compensated cirrhosis.

Methods

PubMed, Scopus, and Web of Science were searched to August 15, 2025, for English-language systematic reviews and meta-analyses. From the included meta-analyses, prognostic performance, heterogeneity, and public

SUBMITTER: Baktikulova K 

PROVIDER: S-EPMC12862496 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature