Obesity Impairs Skin Barrier Function and Facilitates Allergic Sensitization in Mice.

ABSTRACT: Atopic dermatitis is a chronic inflammatory skin condition marked by intense itching and a weakened skin barrier. The compromised skin barrier often leads to exaggerated immune responses and greater sensitivity to allergens. Previous studies have already implicated a link between obesity and atopic dermatitis; however, the mechanisms linking obesity to atopy are not yet well understood. We propose that obesity impairs skin barrier function, facilitating allergen penetration in the skin and triggering systemic and local allergic sensitization. We used a diet-induced obesity mouse model to examine skin barrier integrity and immune responses in both steady-state and inflammatory conditions. In order to induce dermatitis or food allergy, we epicutaneously applied MC903 or ovalbumin, respective

SUBMITTER: Martinek A 

PROVIDER: S-EPMC12862518 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature