Cortisol Regulates PD-1 and IL-12 in Canine Leishmaniasis.

ABSTRACT: Canine visceral leishmaniasis (CanL) is a tropical zoonosis caused by Brazil's protozoan Leishmania (L.) infantum. Disorders in the hypothalamic-pituitary-adrenal (HPA) axis have been reported in human and experimental visceral leishmaniasis, but not yet in canine leishmaniasis. Cortisol is a steroid hormone that regulates several processes, including immune responses. This study investigated HPA axis disorders in dogs with visceral leishmaniasis and their link to clinical and immunological parameters. ELISA quantified serum levels of cortisol and adrenocorticotrophic hormone (ACTH) in 12 healthy dogs and 13 dogs with leishmaniasis. The expression of the enzymes inducible nitric oxide synthase (iNOS) and arginase-1 and programmed cell death protein-1 (PD-1) were evaluated by flow cytometry

SUBMITTER: Ito LTS 

PROVIDER: S-EPMC12862539 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature