Efficacy and Safety of Lisdexamfetamine Versus Topiramate Versus Naltrexone/Bupropion in Individuals With Binge Eating Disorder: A Network Meta-Analysis.

ABSTRACT:

Objective

To compare the efficacy and safety of lisdexamfetamine, topiramate, and naltrexone/bupropion for treating binge eating disorder (BED) using network meta-analysis.

Method

We systematically searched PubMed, Scopus, ClinicalTrials.gov, and Cochrane Central up to February 2025 for randomized controlled trials evaluating these medications versus placebo in adults with BED. Primary outcomes were changes in binge eating frequency and body weight; secondary outcomes included serious adverse events, discontinuation rates, and common side effects. A frequentist random-effects network meta-analysis was performed.

Results

Twelve trials (n = 1988) met inclusion criteria. Both lisdexamfetamine (MD -1.61, 95% CI: -2.41 to -0.81) and topiramate (MD -1.63, 95% CI: -2.53 to -

SUBMITTER: Hodrob T 

PROVIDER: S-EPMC12862547 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature