Skin Lipid-Microbe Interplay Links Staphylococcus hominis to Barrier Control in Adult Atopic Dermatitis.

ABSTRACT:

Background

Skin surface lipids and commensal microbes are essential for the epidermal barrier, but their mutual interactions remain poorly understood.

Methods

We conducted high-resolution shotgun lipidomics of tape strips from lesional and non-lesional atopic dermatitis (AD) skin and healthy controls. Lipidomic data were integrated with 16S amplicon sequencing to construct lipid-microbe interaction networks.

Results

AD skin showed disease-specific lipid-microbe correlations, with less diverse interactions in lesional compared to non-lesional and healthy skin. Staphylococcus hominis (S. hominis) negatively correlated with non-hydroxy-dehydrosphingosine (NdS) 18:0;2/24:0;0 and positively with diacylglycerol (DAG) 18:1;0_18:1;0 and DAG 16:0;0_18:1;0. In vitro co-cultures

SUBMITTER: Bhattacharyya M 

PROVIDER: S-EPMC12862556 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature