Circulating Profiles of the Bile Acid Metabolomics in Patients With Polycystic Ovary Syndrome Treated With Metformin or Canagliflozin.

ABSTRACT:

Objective

Bile acids are indispensable modulators in the development of polycystic ovary syndrome (PCOS). Our previous study identified that metformin and canagliflozin have similar efficacy in patients with PCOS combined with insulin resistance (IR). However, the effect of metformin or canagliflozin on bile acid metabolism in patients with PCOS has not been elucidated. The objective of this study was to use targeted metabolomics technology to compare alterations of circulating bile acid metabolites in patients with PCOS before and after treatment with metformin or canagliflozin.

Design and patients

This study was a subanalysis of a previous randomized open-label study, in which patients with PCOS combined with IR were enrolled and treated with either metformin (n = 35) or c

SUBMITTER: Yan Q 

PROVIDER: S-EPMC12862559 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature