Large-Area Flexible Photopolymerized Scaffolds: Fabrication and Application to Cardiomyocytes.

ABSTRACT: Direct laser writing is a remarkable process for digitally sustainable and fully customized manufacturing of medical components. This study reports on the fabrication of large-area 2D polymer-based scaffolds by ultrashort laser pulses. Designs for scaffolds can be fabricated in minutes over large centimeter areas. They are free-standing, thin, and flexible, with feature sizes down to a few microns. Isotropic and non-isotropic fibrous-like geometries are possible. Scaffolds can be rendered electrically conducting in whole or in part. They have excellent deformability; they can be elastically strained to 20% without fracture. Adhesion, proliferation, and alignment of human-induced pluripotent stem cell-derived cardiomyocytes thrive when deployed on scaffolds. Cells are shown to mature well.

SUBMITTER: Farid N 

PROVIDER: S-EPMC12862759 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature