N-Palmitoyl Glutamine Is a Candidate Mediator of Cardiorespiratory Fitness.

ABSTRACT:

Background

Cardiorespiratory fitness is an integrative measure of cardiometabolic health and predictor of survival, yet little is known about its molecular underpinnings. Small molecule metabolites and lipids are increasingly recognized as exercise-stimulated signaling molecules and candidate molecular transducers of cardiorespiratory fitness.

Methods

We performed nontargeted liquid chromatography mass spectrometry-based plasma metabolomics in 654 participants (mean age, 35 years; 55% women) from the HERITAGE Family Study (Health, Risk Factors, Exercise Training, and Genetics) who had cardiorespiratory fitness (maximal oxygen uptake [VO₂max]) measured by cardiopulmonary exercise testing and underwent 20 weeks of supervised endurance training. Metabolite-VO_2</

SUBMITTER: Robbins JM 

PROVIDER: S-EPMC12862896 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature