Integrating temperature-dependent tissue properties into focused ultrasound computational models for enhanced treatment planning.

ABSTRACT:

Objective

Focused ultrasound (FUS) is a noninvasive therapy that can ablate tissues with precision. Computational simulations using the Pennes Bioheat Transfer Equation (PBTE) can aid FUS treatments by predicting temperature distributions. However, traditional models assume constant thermal and acoustic properties, potentially oversimplifying tissue behavior during treatments.

Methods

This study integrates temperature-dependent thermal properties (thermal conductivity, specific heat capacity, and perfusion) into finite-difference time-domain FUS simulations. Three scenarios were simulated: (1) homogeneous liver with both high- and low-power sonications, (2) rabbit thigh muscle validated against preclinical magnetic resonance temperature imaging (MRTI), and (3) an extended si

SUBMITTER: Valencia Narva C 

PROVIDER: S-EPMC12862921 | biostudies-literature | 2026 Dec

REPOSITORIES: biostudies-literature