<i>METTL14</i> alleviates heat stress in Hu sheep involves enhancing fatty acid oxidation while reducing lipid deposition.

ABSTRACT:

Objective

Heat stress significantly compromises sheep production performance, product quality, and overall health, leading to increased management costs and reduced profitability. Previous studies from our group demonstrated that the m6A methyltransferase gene METTL14 is involved in both the heat stress response and the regulation of lipid metabolism in Hu sheep, suggesting a potential role in mediating heat stress through hepatic metabolic control. However, the specific mechanisms by which METTL14 regulates heat stress and lipid metabolism, as well as the functional linkage between these processes, remain poorly understood.

Methods

We first established heat stress (HS), lipid deposition (LD), and lipid deposition heat stress (LDHS) models in Hu sheep hepatocyt

SUBMITTER: Chen B 

PROVIDER: S-EPMC12862939 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature