Neuro-glial mechanisms underlying sex-based resilience to cardiorespiratory dysfunction in heart failure.

ABSTRACT: Cardiorespiratory disorders, such as sympathoexcitation and disordered breathing, are main hallmarks of chronic heart failure (CHF) associated with high morbidity and mortality. We recently reported that rostral ventrolateral medulla (RVLM) catecholaminergic (C1) neurons are hyperactive in rats with CHF, contributing to cardiorespiratory distress. Notably, CHF without reductions in ejection fraction is more frequent in women than in men, but detailed sex differences in cardiorespiratory pathophysiology, as well as the existence of a sex-dependent neurophysiological remodeling within the RVLM, remain unclear. Therefore, we aimed to characterize sex differences in cardiac, autonomic/respiratory function, RVLM C1 neuron, and glial cell activation, followed by experimentally induced volume ove

SUBMITTER: Pereyra KV 

PROVIDER: S-EPMC12862954 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature