Differential modulation of gestational immunity by fatty acids: tissue-specific immune remodeling and clinical implications.

ABSTRACT: Pregnancy necessitates dynamic maternal metabolic adaptations where fatty acids (FAs) serve dual roles as energy substrates and immunomodulators. However, the effects of specific FAs on gestational immunity and pregnancy outcomes remain elusive. In the present study, we administered saturated palmitic acid (PA), monounsaturated oleic acid (OA), polyunsaturated arachidonic acid (AA), or vehicle solutions daily to pregnant mice (gestational day 0.5 [GD0.5]-7.5) and performed comprehensive immune profiling at GD13.5. Mendelian randomization (MR) analysis was employed to evaluate translational relevance in human pregnancies. AA increased embryo resorption rates and decreased both embryonic and placental weights, aligning with MR evidence linking elevated maternal circulating AA to miscarriage

SUBMITTER: Chen J 

PROVIDER: S-EPMC12862962 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature