Intracoronary adjunctive therapies for ST-elevation myocardial infarction: a network meta-analysis of trials.

ABSTRACT:

Aims

This network meta-analysis of randomized controlled trials (RCTs) evaluates the comparative safety and efficacy of intra-coronary (IC) pharmacological and procedural treatments-on top of balloon angioplasty and stent placement-on clinical outcomes and surrogate endpoints of coronary microvascular obstruction (CMVO) in patients with ST-elevation myocardial infarction (STEMI).

Methods and results

Two electronic databases were searched for eligible studies. Primary efficacy endpoints included all-cause mortality, non-fatal myocardial infarction (MI), and heart failure (HF) hospitalization. Primary safety endpoints included peri-procedural arrhythmias including atrioventricular blocks (AVBs) and ventricular fibrillation/sustained ventricular tachycardia (VF/SVT), any bleedi

SUBMITTER: Laborante R 

PROVIDER: S-EPMC12862973 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature