Electrophysiological diagnosis using the coefficient of variation of R-R intervals and a point-of-care nerve conduction device is highly correlated to the diagnosis of diabetic polyneuropathy using conventional electromyographs.

ABSTRACT:

Aims/introduction

While treatment for diabetic polyneuropathy (DPN) is still developing, progress has stagnated. The alignment between pathological neurodegeneration in DPN and patients' subjective symptoms is often low, yet these symptoms are frequently used for diagnosis. This reliance has hindered the development of effective drugs to prevent neurodegeneration. This study aims to establish an objective electrophysiological diagnostic method that could support future treatment development and validate its accuracy.

Materials and methods

This retrospective multicenter cohort study involved hospitalized diabetic patients. A total of 314 patients underwent nerve conduction studies using standard electromyography and a simplified nerve conduction testing device (NC-stat/DPNChe

SUBMITTER: Himeno T 

PROVIDER: S-EPMC12863008 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature